The dose for your Liver lowers your ALT and AST liver enzymes, starting in two months of daily use, once in the morning. If your enzymes are seriously elevated, take a dose twice daily, once in the morning, before any food, and after dinner. I followed the above regimen, and it worked 100%. My doctors were amazed, and I told them about Dose, so hopefully, they would look into it and prescribe it to their other patients. This is what I recommend.